The PhD dissertation will be defended in English The defence is public. Its product is an exocyst component and may therefore affect lumen formation [25],[42] in supernumerary teats. Fries R, Pausch H Individual genome sequencing of livestock animals – En route to genomic selection 2. Effect of the most significantly associated markers on the estimated breeding value EBV for paternal calving ease pCE in the Fleckvieh breed. BayesB [25] were shown to clearly outperform ‘classical’ genomic prediction using GBLUP for traits which are controlled by large-effect genes [23],[26], [27].

Access to direct phenotypes and genotyping of female animals, respectively, is indispensable to quantify the extent of non-additive effects for the analysed traits. Thus, the current assembly must still be considered as a draft version. The resulting haplotypes were analyzed for association in a multilinear regression model implemented in R see above. The case of the missing heritability. Sichtung der genomischen Variation der Fleckvieh Population durch Re- Sequenzierung bei niedriger bis mittlerer Abdeckung. UC is routinely assessed during the examination of first-crop daughters of test bulls by a score ranging from 1 to 9. Freer B Easy calving – not so difficult.

Qianqian Zhang: Towards Cattle Precision Breeding Using Next Generation Sequencing

The effect of 14 significantly associated SNPs on the proportion of daughters with ambilateral circumocular pigmentation. Confounding due to population stratification was primarily observed in case-control designs when allele frequencies differed between groups due to ancestry [53],[54]. Differentiation; Research in Biological Diversity The heritability of calving traits, i.

However, strong linkage of potentially functional adjacent SNPs often precludes to finally proof the causality of individual variants [35].


hubert pausch dissertation

Assessment of the genomic variation in the Fleckvieh breed by re-sequencing at low dizsertation medium coverage. Since marker alleles with negative effect on pCE have positive effects on growth-related traits, the QTL may exert their effects on the birthing process through fetal growth traits.

Qianqian Zhang: Towards Cattle Precision Breeding Using Next Generation Sequencing

Utilizing breeding values as phenotypes not only compensates smaller sample size in livestock GWAS [7] but also enables QTL mapping for traits which are recorded in the progeny. The pigmentation is restricted to the circumocular area and is not connected to the body pigmentation.

The results indicate that applying dense SNP panels clearly reduces the ‘missing heritability’. Homepage Navigation Content Sitemap Search.

hubert pausch dissertation

Association of 30, SNPs on chromosome 6 with ambilateral circumocular pigmentation in animals of the Fleckvieh population. Investigating a genetic variant of the hubegt hereditary zinc deficiency syndrome in the German Fleckvieh population. Journal of the American Academy of Dermatology Selection of animals carrying favourable QTL alleles might rapidly reduce the incidence of calving difficulties.

Annual Review of Genomics and Human Genetics Eye cancer is the most prevalent malignant pausvh affecting cattle.

Pausch, Hubert, Prof. Dr. | ETH Zurich

The correction was based on axes of variation that met the Jolliffe’s criterion. GWAS have not been performed yet. However, some phenotype patterns are present in few cattle breeds only e. Red numbers indicate chromosomes with identified QTL.

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Natural Selection or Social Preference? Breeding value estimation was based on best linear unbiased prediction BLUP animal model. Recent human effective population size pauscy from linkage disequilibrium. Refinement of a QTL on chromosome 5 associated with milk fat percentage using re-sequencing data. Genome-wide distribution of the proportion of correctly imputed genotypes.


Pigmentation around the eyes is highly correlated with eye-lid and corneoscleral pigmentation [22].

Individual loci explain a large fraction of the genetic variation of complex traits Chapter 4, [17],[41] and dissfrtation fraction of genetic variation captured by SNPs is considerably higher in cattle populations than in humans [42],[43],[44]. The phenomenon of the ‘missing heritability’ The phenomenon of the ‘missing heritability’ [35] was primarily observed in human genetics where researchers were stunned that high-density SNP panels capture only a fraction of the genetic variation of complex traits.

However, in typical livestock populations a limited number of founder animals explains a large proportion of the genetic diversity of breeding populations [49].

These fractions are distinctly higher hubedt those reported for traits with similar heritability in human genetics [49] [1]. Association of 16, SNPs on chromosome 22 with ambilateral circumocular pigmentation in animals of the Fleckvieh population. Help Center Find new research papers in: Exploiting whole genome sequence variants in cattle breeding: Genetics in Agricultural Sciences. For the high-density dataset, 0.

Whole-genome sequencing of bulls facilitates mapping of monogenic and complex traits in cattle.

hubert pausch dissertation

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